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Professor Insoo Park and Sujin Kim’s team identifies effective treatment candidates

Professor Insoo Park, Department of Biomedical Engineering, Konyang University

Professor Insoo Park, Department of Biomedical Engineering, Konyang University

(Daejeon = Larose.VIP) Reporter Chanwook Jeong = At ​​Konyang University, a joint research team led by Professor Insoo Park of the Department of Biomedical Engineering and Professor Sujin Kim of the Department of Biochemistry of the Department of Medicine developed a ‘Lab-on-a-chip’ to evaluate the efficacy of treating Alzheimer’s disease and utilized it. It was announced on the 14th that an effective treatment candidate had been found.

Lab-on-a-Chip is an innovative technology that can reduce the time and cost of developing new drugs by enabling biochemical detection on a small chip, and has recently received great expectations as an alternative research method that can solve ethical problems caused by animal testing.

In this study, the two professors’ team revealed the therapeutic efficacy and mechanism of a substance called neferin, among several candidates for the treatment of Alzheimer’s disease.

Neferin, the main bioactive ingredient of lotus seed, lotus seed, not only inhibits the aggregation of amyloid beta peptide and tau protein, which are known to be the main causative factors of Alzheimer’s disease, but also inhibits neuronal cell death and detoxifies toxic aggregates. It has been proven to be a therapeutic substance that decomposes into a non-existent form.

In addition, through a computer program, the degree of binding between Alzheimer’s disease-causing substances and neferin, binding location, molecular dynamics simulation, absorption, distribution, metabolism, excretion, etc. were predicted.

Professor Kim Soo-jin said, “Using lab-on-a-chip technology, we are conducting research to prove the efficacy of discovered therapeutic candidates and find treatments that can provide practical help to Alzheimer’s disease patients.” He added, “Understanding Alzheimer’s disease.” “I look forward to contributing to the further development of treatment methods,” he said.

The results of this study were recently published online in ‘Biomedicine and Drug Therapy’, an international academic journal in the field of pharmacology and pharmaceuticals.

jchu2000@yna.co.kr

Report to KakaoTalk okjebo 2024/02/14 14:27 Sent

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