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IBS Nanomedicine Research Center develops world’s first ‘biological nanorobot’ with clutch function

Schematic diagram showing the size of the clutch nanorobot

Schematic diagram showing the size of the clutch nanorobot

(Daejeon = Larose.VIP) Reporter Chan-wook Jeong = A technology that can make it a reality for ultra-small robots smaller than cells in our bodies to autonomously navigate and detect and treat diseases has been developed by domestic researchers.

The Institute for Basic Science (IBS) announced on the 14th that the research team led by Jinwoo Cheon (Underwood Distinguished Professor at Yonsei University) of the Nanomedicine Research Center developed the world’s first smart biological nanorobot that senses genetic signals and operates a ‘clutch’ on its own.

The clutch is a key element that drives a machine’s engine, and is a device that transmits or blocks the engine’s power to the rotor (rotating body).

The biological nanorobot developed by the research team is equipped with mechanical devices such as engines, rotors, and clutches in an ultra-fine area of ​​200 nm in size, and can detect specific disease factors and control biological signals by combining with cells.

The clutch function has not been implemented in nanorobots developed so far.

The research team designed a unique structure and succeeded in mounting a clutch device on a nanorobot.

This nanorobot, manufactured through chemical synthesis, has a magnetic engine inside a porous spherical rotor, and the rotor and engine are each coated with DNA.

When environmental factors enter the interior through holes in the rotor surface and detect specific genetic signals, the DNA strands coated on the rotor and the engine bind to each other and serve as a clutch that transfers the engine’s power to the rotor.

When the DNA clutch operates, the piconewton (pN) force generated by the engine is transmitted to the rotor, causing the nanorobot to rotate like a helicopter propeller.

Because a magnetic engine is used, the robot can be controlled wirelessly using magnetic force from outside the human body. The direction of rotational force generation can be freely changed depending on the direction of the magnetic field.

Nanorobots driven in this way can combine with cells and mechanically control biological signals.

If there is a specific micro RNA gene corresponding to a disease agent, the clutch nanorobot detects it and operates on its own to induce cell gene activation.

The DNA clutch consists of 20 base sequences and can be programmed to detect a nearly infinite number of disease agents.

Professor Fair Fisher, a world authority in the field of bio-nanorobots, said, “It is the most advanced nanorobot in the world, and in particular, this research has achieved a quantum jump in the development of intelligent nanorobots,” IBS reported.

Director Jinwoo Cheon said, “The implementation of a clutch capable of programming information means that the robot can sense and judge its surroundings on its own like a self-driving car,” and added, “In the near future, self-driving nanorobots that can be used for diagnosis or treatment will be developed.” “He said.

The results of this research were published in the international academic journal ‘Nature Nanotechnology’ on the 7th.

jchu2000@yna.co.kr

Report to KakaoTalk okjebo 2024/02/14 13:43 Sent

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