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(Seoul = Larose.VIP) Reporter Han Seong-gan = A new fecal test method has been developed that can diagnose colon diseases such as colon polyps and colon cancer by detecting specific proteins in feces that are invisible to the naked eye.

The currently used fecal occult blood test (FIT) targets only hemoglobin, the red protein in red blood cells. When colon disease occurs, bleeding occurs inside the colon. The current fecal occult blood test method is being used to confirm this.

The research team of Dr. Gerrit Mayer, head of the Translational Gastrointestinal Oncology Department at the Netherlands Cancer Institute, has developed a new multi-target fecal occult blood test (mtFIT) that measures two other proteins (calprotectin and serpin) in addition to hemoglobin, HealthDay News ) reported on the 13th.

The research team said that the newly developed test method has higher sensitivity and the same specificity as the existing fecal occult blood test.

Sensitivity and specificity are means of evaluating the accuracy of a test method. Sensitivity refers to the ability to detect a person with a disease as ‘positive’, and specificity refers to the ability to determine a person without a disease as ‘negative’.

The research team compared the difference in diagnostic accuracy by performing this new test method and the existing test method on 13,187 people (ages 55 to 77, 50.3% male).

As a result, 299 people tested positive using the new test method and 159 people tested positive using the existing test method.

The new test method detected relatively large colonic polyps without an increase in ‘false positives’. Therefore, there were few colonoscopy tests for confirmation.

The research team explained that this means that the new test method can reduce the risk of colon cancer by 21% and the risk of death by 18% when evaluated using the FIT positive cutoff currently used in the Netherlands.

The research team said that this new test method can be used as easily as current tests.

However, it is not available for use right away. There remains work to be done so that it can be commercialized in accordance with European diagnostic testing standards. For this purpose, a new company (CRCbioscreen) was established.

The results of this study were published in the latest issue of Lancet Oncology, a British cancer journal.

colon cancer

colon cancer

skhan@yna.co.kr

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