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KIST Dr. Youngmi Jeong “Smart bionic artificial skin… Verification of effectiveness in mice”

(Seoul = Larose.VIP) Reporter Lee Joo-young = A domestic research team has developed artificial skin that can help regenerate skin damaged by nerve tissue due to burns, accidents, skin diseases, etc., and can sense tactile information and transmit it to the nerves. It was effective in mouse model experiments. Confirmed.

Human implantable tactile function smart bionic artificial skin mechanism

Human implantable tactile function smart bionic artificial skin mechanism

The Korea Institute of Science and Technology (KIST) announced on the 18th that the research team of Dr. Young-mi Jeong of the Biomaterials Research Center and Dr. Hyun-jung Lee of the Spin Convergence Research Group, in collaboration with Professor Yoo Ki-jun of Yonsei University and Professor Tae-il Kim of Sungkyunkwan University, developed a smart bionic artificial skin with tactile function that can be implanted in the human body.

Severe skin defects accompanied by nerve tissue damage cause mental and physical pain as well as loss of sensory and cognitive functions essential for life-sustaining activities. Surgical treatment by transplanting artificial skin to the damaged area is possible, but currently developed artificial skin Although it can help skin regeneration by providing a structure and environment similar to skin tissue, it cannot restore sensation.

However, the research team said that the smart bionic artificial skin developed this time can restore even permanently damaged tactile senses by combining highly biocompatible materials that help skin regeneration and a tactile transmission system implemented with electronic devices.

Human implantable tactile function smart bionic artificial skin components

Human implantable tactile function smart bionic artificial skin components

The research team inserted a flexible pressure sensor into artificial skin made of hydrogel composed of collagen and fibrin, the main components of skin, and was able to detect even minute changes in pressure applied to the artificial skin.

Collagen and fibrin artificial skin promotes skin regeneration by triggering the proliferation and differentiation of surrounding skin cells, and the pressure change detected by the sensor is converted into an electrical signal through an electrotactile receptor, and the tactile nerve interfacing electrode transmits this to the nerve. The research team explained.

As a result of transplanting smart bionic artificial skin into mice with severe skin damage, the effect of promoting skin regeneration was found to be more than 120% better than the control group without artificial skin at 14 days after transplantation.

In addition, the flexible pressure sensor detects external pressure of 10 to 40 kPa (kilopascals), which is similar to the pressure range felt by a person’s fingertips, and the electrical signal is adjusted according to the pressure intensity and transmitted to the sciatic nerve connected to the tactile nerve interfacing electrode, It was confirmed that the reaction also varied.

The research team said that smart bionic artificial skin is effective in transmitting sensation and regenerating skin because it is implanted directly into the nerves along the subcutaneous fat layer of damaged skin. Even older people with deteriorated sensory function can recover sensory function by directly inserting tactile function electronic devices under the skin. He said he expected to be able to do it.

Dr. Youngmi Jeong said, “This research is the result of convergence research on devices, materials, and regenerative medicine that combines biomaterials and electronic device technology.” He added, “To commercialize it, we will conduct additional clinical trials in collaboration with medical institutions and companies, and conduct various clinical trials on temperature, vibration, pain, etc. “We plan to expand our research into reconstructing various functions of skin tissue,” he said.

The results of this study were published in the latest issue of the international academic journal Nature Communications.

scitech@yna.co.kr

Report to KakaoTalk okjebo 2024/02/18 12:00 Sent

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