0
Please log in or register to do it.

U.S. research team “Newborn T cells are similar to innate immunity…strong in early response to infection”

(Seoul = Larose.VIP) Reporter Lee Joo-young = Contrary to the existing belief that a newborn’s immune system is an immature version of the adult’s immune system, research results have shown that the functions of T cells, white blood cells that protect against infection and disease, are different.

newborn baby

newborn baby

In the scientific journal Science Immunology on the 24th, the team of Professors Brian Rudd and Andrew Grimson of Cornell University conducted mouse immune system experiments and analyzed data from human fetuses, newborns, and adults, and found that neonatal T cells are similar to the innate immune system, unlike adult T cells. It was revealed that a mechanism that works properly has been confirmed.

The immune system of a newborn has long been considered an immature version of the adult immune system. This idea has been supported by the fact that adult T cells show superior performance than neonatal T cells in antigen recognition, immune memory formation, and response to repeated infections.

However, during the novel coronavirus infection (Corona 19) pandemic, it was revealed that infants had significantly fewer cases than adults, raising questions about the idea that newborn immune systems are weaker than adults, the research team explained.

In this study, the research team found that CD8+ T cells, which are immune cells found in both mice and humans and have been recognized as classical adaptive lymphocytes that recognize specific external antigens and form memory responses, are involved in innate immunity in newborns that fight infections without external antigen stimulation. It was discovered that it does.

In other words, CD8+ T cells from newborns who have never encountered external antigens have a ‘bystander activation’ function that responds to innate cytokines in the absence of T cell receptor (TCR) stimulation.

The research team explained that while adult T cells recognize specific bacteria and later use adaptive immunity to fight them, newborn T cells are activated by proteins related to innate immunity and can quickly respond to bacteria the body has never encountered.

The research team found that neonatal T cells were shown to perform better than adult T cells, especially in fighting some infections.

Professor Rudd said these results show that newborn T cells are not immature or damaged, but simply have different functions from adult T cells. These differences suggest that this is how the immune system provides the most useful functions at each stage of life.

He continued, “Neonatal T cells can do things that most adult T cells cannot, that is, respond to the early stages of infection and defend against pathogens that have not been encountered,” adding, “Adult T cells and neonatal T cells only have different functions. “I can’t say which is better,” he added.

◆ 출처 : Science Immunology, Brian Rudd et al, ‘The gene regulatory basis of bystander activation in CD8+ T cells’, http://dx.doi.org/10.1126/sciimmunol.adf8776

scitech@yna.co.kr

Report to KakaoTalk okjebo 2024/02/24 06:00 Sent

Trump "supports in vitro fertilization"... ‘Frozen embryos are people too’ ruling’s aftermath evolves
“Surprising news that starts with T and includes S”… Ecuador's 'Swift Ona' is excited

Reactions

0
0
0
0
0
0
Already reacted for this post.

Reactions

Your email address will not be published. Required fields are marked *